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Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

Cellular heterogeneity is frequently observed in cancer, but the biological significance of heterogeneous tumor clones is not well defined. Using multicolor reporters and CRISPR-Cas9 barcoding, we trace clonal dynamics in a mouse model of sarcoma. We show that primary tumor growth is associated with...

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Detalles Bibliográficos
Autores principales:	Tang, Yuning J., Huang, Jianguo, Tsushima, Hidetoshi, Ban, Ga I., Zhang, Hongyuan, Oristian, Kristianne M., Puviindran, Vijitha, Williams, Nerissa, Ding, Xiruo, Ou, Jianhong, Jung, Sin-Ho, Lee, Chang-Lung, Jiao, Yiqun, Chen, Benny J., Kirsch, David G., Alman, Benjamin A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750751/ https://www.ncbi.nlm.nih.gov/pubmed/31509746 http://dx.doi.org/10.1016/j.celrep.2019.08.029

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