Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes

[Image: see text] The development of bifunctional imaging probes can often be challenging with difficult and time-consuming solution phase chemistry protocols and purification techniques. A solid phase synthetic protocol was therefore utilized to produce a functionalized derivative of a potent bisma...

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Autores principales: Connah, Liam, Joshi, Rajendra, Vibhute, Sandip, Gambino, Giuseppe, Correia, João D. G., Angelovski, Goran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750874/
https://www.ncbi.nlm.nih.gov/pubmed/31150258
http://dx.doi.org/10.1021/acs.orglett.9b01341
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author Connah, Liam
Joshi, Rajendra
Vibhute, Sandip
Gambino, Giuseppe
Correia, João D. G.
Angelovski, Goran
author_facet Connah, Liam
Joshi, Rajendra
Vibhute, Sandip
Gambino, Giuseppe
Correia, João D. G.
Angelovski, Goran
author_sort Connah, Liam
collection PubMed
description [Image: see text] The development of bifunctional imaging probes can often be challenging with difficult and time-consuming solution phase chemistry protocols and purification techniques. A solid phase synthetic protocol was therefore utilized to produce a functionalized derivative of a potent bismacrocyclic calcium-responsive contrast agent for magnetic resonance imaging. Through a convenient building block approach, the applicability of this methodology in the preparation and simple future development of multifunctional imaging probes was demonstrated.
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spelling pubmed-67508742019-09-19 Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes Connah, Liam Joshi, Rajendra Vibhute, Sandip Gambino, Giuseppe Correia, João D. G. Angelovski, Goran Org Lett [Image: see text] The development of bifunctional imaging probes can often be challenging with difficult and time-consuming solution phase chemistry protocols and purification techniques. A solid phase synthetic protocol was therefore utilized to produce a functionalized derivative of a potent bismacrocyclic calcium-responsive contrast agent for magnetic resonance imaging. Through a convenient building block approach, the applicability of this methodology in the preparation and simple future development of multifunctional imaging probes was demonstrated. American Chemical Society 2019-05-31 2019-07-19 /pmc/articles/PMC6750874/ /pubmed/31150258 http://dx.doi.org/10.1021/acs.orglett.9b01341 Text en Copyright © 2019 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Connah, Liam
Joshi, Rajendra
Vibhute, Sandip
Gambino, Giuseppe
Correia, João D. G.
Angelovski, Goran
Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes
title Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes
title_full Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes
title_fullStr Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes
title_full_unstemmed Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes
title_short Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes
title_sort solid-phase-supported approach for the preparation of bioresponsive and multifunctional mri probes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750874/
https://www.ncbi.nlm.nih.gov/pubmed/31150258
http://dx.doi.org/10.1021/acs.orglett.9b01341
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