Cargando…

Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner

PURPOSE: Fibronectin fibrillogenesis is an integrin-mediated process that may contribute to the pathogenesis of primary open-angle glaucoma (POAG). Here, we examined the effects of αvβ3 integrins on fibrillogenesis in immortalized TM-1 cells and human trabecular meshwork (HTM) cells. METHODS: TM-1 c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Filla, Mark S., Faralli, Jennifer A., Desikan, Harini, Peotter, Jennifer L., Wannow, Abigail C., Peters, Donna M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750892/ https://www.ncbi.nlm.nih.gov/pubmed/31529121 http://dx.doi.org/10.1167/iovs.19-27171

Ejemplares similares

Genomic/proteomic analyses of dexamethasone-treated human trabecular meshwork cells reveal a role for GULP1 and ABR in phagocytosis
por: Faralli, Jennifer A., et al.
Publicado: (2019)

Effect of αvβ3 Integrin Expression and Activity on Intraocular Pressure
por: Faralli, Jennifer A., et al.
Publicado: (2019)

Integrin Crosstalk and Its Effect on the Biological Functions of the Trabecular Meshwork/Schlemm’s Canal
por: Faralli, Jennifer A., et al.
Publicado: (2022)

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway
por: Wang, Yiwen, et al.
Publicado: (2019)

Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells
por: Filla, Mark S., et al.
Publicado: (2021)

Dexamethasone and Glucocorticoid-Induced Matrix Temporally Modulate Key Integrins, Caveolins, Contractility, and Stiffness in Human Trabecular Meshwork Cells
por: Yemanyi, Felix, et al.
Publicado: (2020)

Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome
por: Yan, Xiaoqin, et al.
Publicado: (2022)

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone
por: Zhu, Xiaofeng, et al.
Publicado: (2023)

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2018)

Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork
por: Aktas, Zeynep, et al.
Publicado: (2018)

Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging
por: Wang, Ke, et al.
Publicado: (2017)

Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells
por: Sun, Ying Ying, et al.
Publicado: (2019)

A Porcine Anterior Segment Perfusion and Transduction Model With Direct Visualization of the Trabecular Meshwork
por: Loewen, Ralitsa T., et al.
Publicado: (2016)

Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells
por: Keller, Kate E., et al.
Publicado: (2017)

Effects of Lentivirus-Mediated C3 Expression on Trabecular Meshwork Cells and Intraocular Pressure
por: Tan, Junka, et al.
Publicado: (2018)

The Molecular Processes in the Trabecular Meshwork After Exposure to Corticosteroids and in Corticosteroid-Induced Ocular Hypertension
por: Liesenborghs, Ilona, et al.
Publicado: (2020)

Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells
por: MacDonald, William W., et al.
Publicado: (2022)

HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
por: Bermudez, Jaclyn Y., et al.
Publicado: (2016)

Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation
por: Sun, Ying Ying, et al.
Publicado: (2019)

Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype
por: Dhamodaran, Kamesh, et al.
Publicado: (2020)

Osthole Reduces Mouse IOP Associated With Ameliorating Extracellular Matrix Expression of Trabecular Meshwork Cell
por: Fan, Yuchen, et al.
Publicado: (2020)

NFATc1 Regulation of Dexamethasone-Induced TGFB2 Expression Is Cell Cycle Dependent in Trabecular Meshwork Cells
por: Filla, Mark S., et al.
Publicado: (2023)

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork
por: Kasetti, Ramesh B., et al.
Publicado: (2016)

Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2017)

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology
por: Ashok, Ajay, et al.
Publicado: (2020)

A Porcine Organ-Culture Glaucoma Model Mimicking Trabecular Meshwork Damage Using Oxidative Stress
por: Snider, Eric J., et al.
Publicado: (2021)

Growth Differentiation Factor-15–Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells
por: Muralidharan, Arumugam Ramachandran, et al.
Publicado: (2016)

Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch
por: Youngblood, Hannah, et al.
Publicado: (2020)

Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells
por: Ho, Leona T. Y., et al.
Publicado: (2018)

The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model
por: Deng, Chaohua, et al.
Publicado: (2020)

Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice
por: De Groef, Lies, et al.
Publicado: (2016)

Crosslinked Extracellular Matrix Stiffens Human Trabecular Meshwork Cells Via Dysregulating β-catenin and YAP/TAZ Signaling Pathways
por: Yemanyi, Felix, et al.
Publicado: (2020)

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression
por: Rao, Vidhya R., et al.
Publicado: (2021)

Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography
por: Gao, Kai, et al.
Publicado: (2020)

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma
por: Zhu, Wei, et al.
Publicado: (2017)

Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells
por: Yemanyi, Felix, et al.
Publicado: (2020)

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma
por: Sui, Shangru, et al.
Publicado: (2021)

Role of Fibronectin in Primary Open Angle Glaucoma
por: Faralli, Jennifer A., et al.
Publicado: (2019)

TGFβ2 Induces the Formation of Cross-Linked Actin Networks (CLANs) in Human Trabecular Meshwork Cells Through the Smad and Non-Smad Dependent Pathways
por: Montecchi-Palmer, Michela, et al.
Publicado: (2017)

Metformin protects trabecular meshwork against oxidative injury via activating integrin/ROCK signals
por: Xu, Lijuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_85qs6k894prfg67215pfgi5vi6