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Increasing the Potential of the Auristatin Cancer-Drug Family by Shifting the Conformational Equilibrium

[Image: see text] Monomethyl auristatin E and monomethyl auristatin F are widely used cytotoxic agents in antibody–drug conjugates (ADCs), a group of promising cancer drugs. The ADCs specifically target cancer cells, releasing the auristatins inside, which results in the prevention of mitosis. The a...

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Detalles Bibliográficos
Autores principales:	Sokka, Iris K., Ekholm, Filip S., Johansson, Mikael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750905/ https://www.ncbi.nlm.nih.gov/pubmed/31199662 http://dx.doi.org/10.1021/acs.molpharmaceut.9b00437

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