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SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors

The cyclin-dependent kinase 4/6 (CDK4/6) kinase is dysregulated in melanoma, highlighting it as a potential therapeutic target. CDK4/6 inhibitors are being evaluated in trials for melanoma and additional cancers. While beneficial, resistance to therapy is a concern, and the molecular mechanisms of s...

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Detalles Bibliográficos
Autores principales:	Yoshida, Akihiro, Bu, Yiwen, Qie, Shuo, Wrangle, John, Camp, E. Ramsay, Hazard, E. Starr, Hardiman, Gary, de Leeuw, Renée, Knudsen, Karen E., Diehl, J. Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750908/ https://www.ncbi.nlm.nih.gov/pubmed/31555743 http://dx.doi.org/10.1126/sciadv.aax6352

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