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Structural basis of sterol recognition by human hedgehog receptor PTCH1

Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM...

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Detalles Bibliográficos
Autores principales:	Qi, Chao, Di Minin, Giulio, Vercellino, Irene, Wutz, Anton, Korkhov, Volodymyr M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750913/ https://www.ncbi.nlm.nih.gov/pubmed/31555730 http://dx.doi.org/10.1126/sciadv.aaw6490

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