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Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations in its autoregulatory middle domain (MD) to mitigate toxic misfolding of TDP-43, FUS, and α-synuclein implicated in fatal neurodegenerative disorders. Problematically, potentiated MD variants can exhibit off-targe...

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Detalles Bibliográficos
Autores principales:	Tariq, Amber, Lin, JiaBei, Jackrel, Meredith E., Hesketh, Christina D., Carman, Peter J., Mack, Korrie L., Weitzman, Rachel, Gambogi, Craig, Murillo, Oscar A. Hernandez, Sweeny, Elizabeth A., Gurpinar, Esin, Yokom, Adam L., Gates, Stephanie N., Yee, Keolamau, Sudesh, Saurabh, Stillman, Jacob, Rizo, Alexandra N., Southworth, Daniel R., Shorter, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750954/ https://www.ncbi.nlm.nih.gov/pubmed/31433984 http://dx.doi.org/10.1016/j.celrep.2019.07.069

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