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Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

Strains of Pseudomonas aeruginosa with deficiencies in DNA mismatch repair have been studied in the context of chronic infection, where elevated mutational rates (“hypermutation”) may facilitate the acquisition of antimicrobial resistance. Whether P. aeruginosa hypermutation can also play an adaptiv...

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Detalles Bibliográficos
Autores principales:	Khil, Pavel P., Dulanto Chiang, Augusto, Ho, Jonathan, Youn, Jung-Ho, Lemon, Jamie K., Gea-Banacloche, Juan, Frank, Karen M., Parta, Mark, Bonomo, Robert A., Dekker, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751058/ https://www.ncbi.nlm.nih.gov/pubmed/31530672 http://dx.doi.org/10.1128/mBio.01822-19

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