ER stress and UPR activation in glioblastoma: identification of a noncanonical PERK mechanism regulating GBM stem cells through SOX2 modulation

Patients with aggressive brain tumors, named glioblastoma multiforme (GBM), have a poor prognoses. Here we explored if the ER stress/unfolded protein response (UPR) is involved in the pathophysiology of GBM and may provide novel therapeutic targets. Immunohistochemical analyses of a tissue microarra...

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Detalles Bibliográficos
Autores principales: Peñaranda-Fajardo, Natalia M., Meijer, Coby, Liang, Yuanke, Dijkstra, Bianca M., Aguirre-Gamboa, Raul, den Dunnen, Wilfred F. A., Kruyt, Frank A. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751174/
https://www.ncbi.nlm.nih.gov/pubmed/31534165
http://dx.doi.org/10.1038/s41419-019-1934-1

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