Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system

The pathophysiological role of mammalian target of rapamycin complex 1 (mTORC1) in neurodegenerative diseases is established, but possible therapeutic targets responsible for its activation in neurons must be explored. Here we identified solute carrier family 38a member 1 (SNAT1, Slc38a1) as a posit...

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Detalles Bibliográficos
Autores principales: Yamada, Daisuke, Kawabe, Kenji, Tosa, Ikue, Tsukamoto, Shunpei, Nakazato, Ryota, Kou, Miki, Fujikawa, Koichi, Nakamura, Saki, Ono, Mitsuaki, Oohashi, Toshitaka, Kaneko, Mari, Go, Shioi, Hinoi, Eiichi, Yoneda, Yukio, Takarada, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751179/
https://www.ncbi.nlm.nih.gov/pubmed/31552299
http://dx.doi.org/10.1038/s42003-019-0582-4

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