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The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience
Pre-pubertal stress increases post-traumatic stress disorder (PTSD) susceptibility. We have previously demonstrated that enriched environment (EE) intervention immediately after pre-pubertal stress protects from the effects of trauma in adulthood. Here, we examined whether exposure to EE would also...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751196/ https://www.ncbi.nlm.nih.gov/pubmed/31534228 http://dx.doi.org/10.1038/s41598-019-49824-4 |
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author | Ardi, Z. Richter-Levin, A. Xu, L. Cao, X. Volkmer, H. Stork, O. Richter-Levin, G. |
author_facet | Ardi, Z. Richter-Levin, A. Xu, L. Cao, X. Volkmer, H. Stork, O. Richter-Levin, G. |
author_sort | Ardi, Z. |
collection | PubMed |
description | Pre-pubertal stress increases post-traumatic stress disorder (PTSD) susceptibility. We have previously demonstrated that enriched environment (EE) intervention immediately after pre-pubertal stress protects from the effects of trauma in adulthood. Here, we examined whether exposure to EE would also be beneficial if applied after exposure to trauma in adulthood. We have recently shown that exposure to juvenile stress and under-water trauma (UWT) is associated with increased expression of GABA(A) receptor subunit α1 in the ventral hippocampus. However, differentiating between affected and unaffected individuals, this increased expression was confined to stress-exposed, behaviorally unaffected individuals, suggesting upregulation of α1 expression as a potential mechanism of resilience. We now examined whether EE-induced resilience renders increased expression of α1 in the ventral hippocampus redundant when facing a trauma later in life. Adult rats were exposed to UWT, with pre-exposure to juvenile stress, and tested in the open field and elevated plus maze paradigms four weeks later. EE exposure during juvenility prevented pre-pubertal stress-induced vulnerability, but not if performed following UWT in adulthood. Furthermore, juvenile EE exposure prevented the trauma-associated increase in α1 expression levels. Our findings emphasize the importance of early interventions in order to reduce the likelihood of developing psychopathologies in adulthood. |
format | Online Article Text |
id | pubmed-6751196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67511962019-09-30 The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience Ardi, Z. Richter-Levin, A. Xu, L. Cao, X. Volkmer, H. Stork, O. Richter-Levin, G. Sci Rep Article Pre-pubertal stress increases post-traumatic stress disorder (PTSD) susceptibility. We have previously demonstrated that enriched environment (EE) intervention immediately after pre-pubertal stress protects from the effects of trauma in adulthood. Here, we examined whether exposure to EE would also be beneficial if applied after exposure to trauma in adulthood. We have recently shown that exposure to juvenile stress and under-water trauma (UWT) is associated with increased expression of GABA(A) receptor subunit α1 in the ventral hippocampus. However, differentiating between affected and unaffected individuals, this increased expression was confined to stress-exposed, behaviorally unaffected individuals, suggesting upregulation of α1 expression as a potential mechanism of resilience. We now examined whether EE-induced resilience renders increased expression of α1 in the ventral hippocampus redundant when facing a trauma later in life. Adult rats were exposed to UWT, with pre-exposure to juvenile stress, and tested in the open field and elevated plus maze paradigms four weeks later. EE exposure during juvenility prevented pre-pubertal stress-induced vulnerability, but not if performed following UWT in adulthood. Furthermore, juvenile EE exposure prevented the trauma-associated increase in α1 expression levels. Our findings emphasize the importance of early interventions in order to reduce the likelihood of developing psychopathologies in adulthood. Nature Publishing Group UK 2019-09-18 /pmc/articles/PMC6751196/ /pubmed/31534228 http://dx.doi.org/10.1038/s41598-019-49824-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ardi, Z. Richter-Levin, A. Xu, L. Cao, X. Volkmer, H. Stork, O. Richter-Levin, G. The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience |
title | The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience |
title_full | The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience |
title_fullStr | The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience |
title_full_unstemmed | The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience |
title_short | The role of the GABAA receptor Alpha 1 subunit in the ventral hippocampus in stress resilience |
title_sort | role of the gabaa receptor alpha 1 subunit in the ventral hippocampus in stress resilience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751196/ https://www.ncbi.nlm.nih.gov/pubmed/31534228 http://dx.doi.org/10.1038/s41598-019-49824-4 |
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