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Epigenome editing strategies for the functional annotation of CTCF insulators

The human genome is folded into regulatory units termed ‘topologically-associated domains’ (TADs). Genome-wide studies support a global role for the insulator protein CTCF in mediating chromosomal looping and the topological constraint of TAD boundaries. However, the impact of individual insulators...

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Detalles Bibliográficos
Autores principales:	Tarjan, Daniel R., Flavahan, William A., Bernstein, Bradley E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751197/ https://www.ncbi.nlm.nih.gov/pubmed/31534142 http://dx.doi.org/10.1038/s41467-019-12166-w

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