Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein

The C-terminal binding protein (CtBP) is an NADH-dependent dimeric family of nuclear proteins that scaffold interactions between transcriptional regulators and chromatin-modifying complexes. Its association with poor survival in several cancers implicates CtBP as a promising target for pharmacologic...

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Detalles Bibliográficos
Autores principales: Byun, Jung S., Park, Samson, Yi, Dae Ik, Shin, Jee-Hye, Hernandez, Sara Gil, Hewitt, Stephen M., Nicklaus, Marc C., Peach, Megan L., Guasch, Laura, Tang, Binwu, Wakefield, Lalage M., Yan, Tingfen, Caban, Ambar, Jones, Alana, Kabbout, Mohamed, Vohra, Nasreen, Nápoles, Anna María, Singhal, Sandeep, Yancey, Ryan, De Siervi, Adriana, Gardner, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751206/
https://www.ncbi.nlm.nih.gov/pubmed/31534138
http://dx.doi.org/10.1038/s41419-019-1892-7

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