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A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of 53BP1 to DNA lesions impairs mitotic fidelity. Pr...

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Detalles Bibliográficos
Autores principales:	Zheng, Xiao-Feng, Acharya, Sanket S., Choe, Katherine N., Nikhil, Kumar, Adelmant, Guillaume, Satapathy, Shakti Ranjan, Sharma, Samanta, Viccaro, Keith, Rana, Sandeep, Natarajan, Amarnath, Sicinski, Peter, Marto, Jarrod A., Shah, Kavita, Chowdhury, Dipanjan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751209/ https://www.ncbi.nlm.nih.gov/pubmed/31534152 http://dx.doi.org/10.1038/s41467-019-12084-x

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