Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache

Medication-overuse headaches (MOH) occur with both over-the-counter and pain-relief medicines, including paracetamol, opioids and combination analgesics. The mechanisms that lead to MOH are still uncertain. Here, we show that abnormal activation of Nav1.9 channels by Nitric Oxide (NO) is responsible...

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Detalles Bibliográficos
Autores principales: Bonnet, Caroline, Hao, Jizhe, Osorio, Nancy, Donnet, Anne, Penalba, Virginie, Ruel, Jérôme, Delmas, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751217/
https://www.ncbi.nlm.nih.gov/pubmed/31534133
http://dx.doi.org/10.1038/s41467-019-12197-3

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