[(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years

[(11)C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation react...

Descripción completa

Detalles Bibliográficos
Autores principales: Taddei, Carlotta, Pike, Victor W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751244/
https://www.ncbi.nlm.nih.gov/pubmed/31659516
http://dx.doi.org/10.1186/s41181-019-0073-4
_version_ 1783452581977128960
author Taddei, Carlotta
Pike, Victor W.
author_facet Taddei, Carlotta
Pike, Victor W.
author_sort Taddei, Carlotta
collection PubMed
description [(11)C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years.
format Online
Article
Text
id pubmed-6751244
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-67512442019-10-04 [(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years Taddei, Carlotta Pike, Victor W. EJNMMI Radiopharm Chem Review [(11)C]Carbon monoxide is an appealing synthon for introducing carbon-11 at a carbonyl position (C=O) in a wide variety of chemotypes (e.g., amides, ketones, acids, esters, and ureas). The prevalence of the carbonyl group in drug molecules and the present-day broad versatility of carbonylation reactions have led to an upsurge in the production of this synthon and in its application to PET radiotracer development. This review focuses on the major advances of the past 15 years. Springer International Publishing 2019-09-18 /pmc/articles/PMC6751244/ /pubmed/31659516 http://dx.doi.org/10.1186/s41181-019-0073-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Taddei, Carlotta
Pike, Victor W.
[(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
title [(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
title_full [(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
title_fullStr [(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
title_full_unstemmed [(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
title_short [(11)C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years
title_sort [(11)c]carbon monoxide: advances in production and application to pet radiotracer development over the past 15 years
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751244/
https://www.ncbi.nlm.nih.gov/pubmed/31659516
http://dx.doi.org/10.1186/s41181-019-0073-4
work_keys_str_mv AT taddeicarlotta 11ccarbonmonoxideadvancesinproductionandapplicationtopetradiotracerdevelopmentoverthepast15years
AT pikevictorw 11ccarbonmonoxideadvancesinproductionandapplicationtopetradiotracerdevelopmentoverthepast15years

Ejemplares similares