In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy

Many studies of tauopathy use transgenic mice that overexpress the P301S mutant form of tau. Neuronal damage in these mice is associated with astrogliosis and induction of glial fibrillary acidic protein (GFAP) expression. GFAP-luc transgenic mice express firefly luciferase under the GFAP promoter,...

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Detalles Bibliográficos
Autores principales: Dunn-Meynell, Ambrose A., Dowling, Peter, Marchese, Michelle, Rodriguez, Esther, Blumberg, Benjamin, Choi, Yun-Beom, Gaindh, Deeya, Lu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751306/
https://www.ncbi.nlm.nih.gov/pubmed/31572168
http://dx.doi.org/10.3389/fnagi.2019.00252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751306/
https://www.ncbi.nlm.nih.gov/pubmed/31572168
http://dx.doi.org/10.3389/fnagi.2019.00252

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