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Protective and Regenerative Roles of T Cells in Central Nervous System Disorders
Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751344/ https://www.ncbi.nlm.nih.gov/pubmed/31572381 http://dx.doi.org/10.3389/fimmu.2019.02171 |
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author | Evans, Frances L. Dittmer, Marie de la Fuente, Alerie G. Fitzgerald, Denise C. |
author_facet | Evans, Frances L. Dittmer, Marie de la Fuente, Alerie G. Fitzgerald, Denise C. |
author_sort | Evans, Frances L. |
collection | PubMed |
description | Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to the diversity of T cell subsets, particularly CD4(+) T cells. Here, we review the beneficial impact of T cell subsets in a range of neuroinflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and CNS trauma. Both T cell-secreted mediators and direct cell contact-dependent mechanisms deliver neuroprotective, neuroregenerative and immunomodulatory signals in these settings. Understanding the molecular details of these beneficial T cell mechanisms will provide novel targets for therapeutic exploitation that can be applied to a range of neurological disorders. |
format | Online Article Text |
id | pubmed-6751344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67513442019-09-30 Protective and Regenerative Roles of T Cells in Central Nervous System Disorders Evans, Frances L. Dittmer, Marie de la Fuente, Alerie G. Fitzgerald, Denise C. Front Immunol Immunology Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to the diversity of T cell subsets, particularly CD4(+) T cells. Here, we review the beneficial impact of T cell subsets in a range of neuroinflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and CNS trauma. Both T cell-secreted mediators and direct cell contact-dependent mechanisms deliver neuroprotective, neuroregenerative and immunomodulatory signals in these settings. Understanding the molecular details of these beneficial T cell mechanisms will provide novel targets for therapeutic exploitation that can be applied to a range of neurological disorders. Frontiers Media S.A. 2019-09-12 /pmc/articles/PMC6751344/ /pubmed/31572381 http://dx.doi.org/10.3389/fimmu.2019.02171 Text en Copyright © 2019 Evans, Dittmer, de la Fuente and Fitzgerald. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Evans, Frances L. Dittmer, Marie de la Fuente, Alerie G. Fitzgerald, Denise C. Protective and Regenerative Roles of T Cells in Central Nervous System Disorders |
title | Protective and Regenerative Roles of T Cells in Central Nervous System Disorders |
title_full | Protective and Regenerative Roles of T Cells in Central Nervous System Disorders |
title_fullStr | Protective and Regenerative Roles of T Cells in Central Nervous System Disorders |
title_full_unstemmed | Protective and Regenerative Roles of T Cells in Central Nervous System Disorders |
title_short | Protective and Regenerative Roles of T Cells in Central Nervous System Disorders |
title_sort | protective and regenerative roles of t cells in central nervous system disorders |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751344/ https://www.ncbi.nlm.nih.gov/pubmed/31572381 http://dx.doi.org/10.3389/fimmu.2019.02171 |
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