Cargando…

Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer’s Disease

BACKGROUND: Death-Associated Protein Kinase 1 (DAPK1) plays an important role in apopto-sis, tumor suppression and neurodegeneration including Alzheimer’s Disease (AD). OBJECTIVE: This review will describe the diverse roles of DAPK1 in the development of cancer and AD, and the current status of drug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Dongmei, Zhou, Xiao Z., Lee, Tae H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751350/ https://www.ncbi.nlm.nih.gov/pubmed/30569876 http://dx.doi.org/10.2174/1574892814666181218170257

Ejemplares similares

Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease
por: Kim, Nami, et al.
Publicado: (2019)

Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease
por: Zhang, Tao, et al.
Publicado: (2022)

Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets
por: Fišar, Zdeněk
Publicado: (2022)

Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy
por: Pang, Xiao-Jing, et al.
Publicado: (2021)

Targeting HDACs: A Promising Therapy for Alzheimer's Disease
por: Xu, Ke, et al.
Publicado: (2011)

Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice
por: Gan, Chen-Ling, et al.
Publicado: (2021)

G-Quadruplex-Binding Proteins: Promising Targets for Drug Design
por: Shu, Huiling, et al.
Publicado: (2022)

Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases
por: Zhai, Yuhong, et al.
Publicado: (2021)

Slow Wave Sleep Is a Promising Intervention Target for Alzheimer’s Disease
por: Lee, Yee Fun, et al.
Publicado: (2020)

Targeting Endothelin in Alzheimer's Disease: A Promising Therapeutic Approach
por: Sharma, Shiwali, et al.
Publicado: (2021)

Promising drug targets and associated therapeutic interventions in Parkinson’s disease
por: Rai, Sachchida Nand, et al.
Publicado: (2021)

Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease
por: Suo, William Z., et al.
Publicado: (2010)

Programmed Cell Death Protein 1 Blockade Reduces Glycogen Synthase Kinase 3β Activity and Tau Hyperphosphorylation in Alzheimer’s Disease Mouse Models
por: Zou, Yulian, et al.
Publicado: (2021)

Choline Kinase Emerges as a Promising Drug Target in Gram-Positive Bacteria
por: Zimmerman, Tahl, et al.
Publicado: (2019)

TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
por: Zhou, Yongji, et al.
Publicado: (2020)

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease
por: Islam Khan, Rubayat, et al.
Publicado: (2018)

Ablation of Death-Associated Protein Kinase 1 Changes the Transcriptomic Profile and Alters Neural-Related Pathways in the Brain
por: Li, Ruomeng, et al.
Publicado: (2023)

The mitochondrial death pathway: a promising therapeutic target in diseases
por: Gupta, Sanjeev, et al.
Publicado: (2009)

Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies
por: Feng, Yuanyuan, et al.
Publicado: (2017)

The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease
por: Cellai, Lucrezia, et al.
Publicado: (2018)

Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease
por: Mamun, Abdullah Al, et al.
Publicado: (2020)

Targeting calcium signaling in Alzheimer’s disease: challenges and promising therapeutic avenues
por: Song, LinLin, et al.
Publicado: (2023)

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease
por: Menting, Kelly Willemijn, et al.
Publicado: (2014)

Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy
por: Chumakov, Ilya, et al.
Publicado: (2015)

Molecular identification of protein kinase C beta in Alzheimer's disease
por: Zhou, Zhike, et al.
Publicado: (2020)

Protein Kinases as Drug Development Targets for Heart Disease Therapy
por: Dhalla, Naranjan S., et al.
Publicado: (2010)

Aurora-A Kinase as a Promising Therapeutic Target in Cancer
por: D’Assoro, Antonino B., et al.
Publicado: (2016)

Benzimidazole-Based Schiff Base Hybrid Scaffolds: A Promising Approach to Develop Multi-Target Drugs for Alzheimer’s Disease
por: Hussain, Rafaqat, et al.
Publicado: (2023)

Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function
por: Kim, B M, et al.
Publicado: (2014)

Erratum to: Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer’s Disease
por: Wei, Hui, et al.
Publicado: (2020)

Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets?
por: Moreth, Jens, et al.
Publicado: (2013)

Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?
por: Vecchio, Filomena Lo, et al.
Publicado: (2022)

Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer's Disease
por: Wu, Linyu, et al.
Publicado: (2022)

miRNAs and Stem Cells as Promising Diagnostic and Therapeutic Targets for Alzheimer’s Disease
por: Elzayat, Emad M., et al.
Publicado: (2023)

Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge
por: Wang, Ya, et al.
Publicado: (2022)

Phosphorylation Signaling in APP Processing in Alzheimer’s Disease
por: Zhang, Tao, et al.
Publicado: (2019)

Protein Drug Targets of Lavandula angustifolia on treatment of Rat Alzheimer's Disease
por: Zali, Hakimeh, et al.
Publicado: (2015)

Covalent Warheads Targeting Cysteine Residue: The Promising Approach in Drug Development
por: Huang, Fangjiao, et al.
Publicado: (2022)

Chronic Neuroinflammation in Alzheimer's Disease: New Perspectives on Animal Models and Promising Candidate Drugs
por: Millington, Christopher, et al.
Publicado: (2014)

Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
por: Ansari, Niloufar, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gseh579sm2urcsb9b0bok72lpk