Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment

We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distanc...

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Autores principales: Goukasian, Naira, Porat, Shai, Blanken, Anna, Avila, David, Zlatev, Dimitar, Hurtz, Sona, Hwang, Kristy S., Pierce, Jonathan, Joshi, Shantanu H., Woo, Ellen, Apostolova, Liana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751474/
https://www.ncbi.nlm.nih.gov/pubmed/31572424
http://dx.doi.org/10.1159/000490044
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author Goukasian, Naira
Porat, Shai
Blanken, Anna
Avila, David
Zlatev, Dimitar
Hurtz, Sona
Hwang, Kristy S.
Pierce, Jonathan
Joshi, Shantanu H.
Woo, Ellen
Apostolova, Liana G.
author_facet Goukasian, Naira
Porat, Shai
Blanken, Anna
Avila, David
Zlatev, Dimitar
Hurtz, Sona
Hwang, Kristy S.
Pierce, Jonathan
Joshi, Shantanu H.
Woo, Ellen
Apostolova, Liana G.
author_sort Goukasian, Naira
collection PubMed
description We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method. Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors.
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spelling pubmed-67514742019-09-30 Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment Goukasian, Naira Porat, Shai Blanken, Anna Avila, David Zlatev, Dimitar Hurtz, Sona Hwang, Kristy S. Pierce, Jonathan Joshi, Shantanu H. Woo, Ellen Apostolova, Liana G. Dement Geriatr Cogn Dis Extra Research Article We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method. Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors. S. Karger AG 2019-08-13 /pmc/articles/PMC6751474/ /pubmed/31572424 http://dx.doi.org/10.1159/000490044 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
spellingShingle Research Article
Goukasian, Naira
Porat, Shai
Blanken, Anna
Avila, David
Zlatev, Dimitar
Hurtz, Sona
Hwang, Kristy S.
Pierce, Jonathan
Joshi, Shantanu H.
Woo, Ellen
Apostolova, Liana G.
Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
title Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
title_full Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
title_fullStr Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
title_full_unstemmed Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
title_short Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment
title_sort cognitive correlates of hippocampal atrophy and ventricular enlargement in adults with or without mild cognitive impairment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751474/
https://www.ncbi.nlm.nih.gov/pubmed/31572424
http://dx.doi.org/10.1159/000490044
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