Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia

There is a lack of pharmacological interventions available for sarcopenia, a progressive age-associated loss of muscle mass, leading to a decline in mobility and quality of life. We found mTORC1 (mammalian target of rapamycin complex 1), a well-established positive modulator of muscle mass, to be su...

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Detalles Bibliográficos
Autores principales: Joseph, Giselle A., Wang, Sharon X., Jacobs, Cody E., Zhou, Weihua, Kimble, Garrett C., Tse, Herman W., Eash, John K., Shavlakadze, Tea, Glass, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751631/
https://www.ncbi.nlm.nih.gov/pubmed/31308131
http://dx.doi.org/10.1128/MCB.00141-19

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