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Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
[Image: see text] A novel formic acid-assisted rapid and efficient route for C–S bond construction via the thiol–ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing differe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751736/ https://www.ncbi.nlm.nih.gov/pubmed/31552354 http://dx.doi.org/10.1021/acsomega.9b01968 |
Sumario: | [Image: see text] A novel formic acid-assisted rapid and efficient route for C–S bond construction via the thiol–ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing different functionalities were well tolerated. The reaction also provided a good yield of sulfones in a one-pot two-step protocol. The developed method is operationally simple, green, metal-free, solvent-free, and having a high atom economy with high regioselectivity. |
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