Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes

[Image: see text] A novel formic acid-assisted rapid and efficient route for C–S bond construction via the thiol–ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing differe...

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Autores principales: Upadhyay, Rahul, Rana, Rohit, Sood, Aakriti, Maurya, Sushil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751736/
https://www.ncbi.nlm.nih.gov/pubmed/31552354
http://dx.doi.org/10.1021/acsomega.9b01968
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author Upadhyay, Rahul
Rana, Rohit
Sood, Aakriti
Maurya, Sushil K.
author_facet Upadhyay, Rahul
Rana, Rohit
Sood, Aakriti
Maurya, Sushil K.
author_sort Upadhyay, Rahul
collection PubMed
description [Image: see text] A novel formic acid-assisted rapid and efficient route for C–S bond construction via the thiol–ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing different functionalities were well tolerated. The reaction also provided a good yield of sulfones in a one-pot two-step protocol. The developed method is operationally simple, green, metal-free, solvent-free, and having a high atom economy with high regioselectivity.
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spelling pubmed-67517362019-09-24 Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes Upadhyay, Rahul Rana, Rohit Sood, Aakriti Maurya, Sushil K. ACS Omega [Image: see text] A novel formic acid-assisted rapid and efficient route for C–S bond construction via the thiol–ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing different functionalities were well tolerated. The reaction also provided a good yield of sulfones in a one-pot two-step protocol. The developed method is operationally simple, green, metal-free, solvent-free, and having a high atom economy with high regioselectivity. American Chemical Society 2019-09-04 /pmc/articles/PMC6751736/ /pubmed/31552354 http://dx.doi.org/10.1021/acsomega.9b01968 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Upadhyay, Rahul
Rana, Rohit
Sood, Aakriti
Maurya, Sushil K.
Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
title Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
title_full Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
title_fullStr Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
title_full_unstemmed Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
title_short Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes
title_sort formic acid-driven rapid and green anti-markovnikov hydrothiolation of styrenes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751736/
https://www.ncbi.nlm.nih.gov/pubmed/31552354
http://dx.doi.org/10.1021/acsomega.9b01968
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