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Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage
BACKGROUND: In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is the reported use of analgesics. We determined surrogate parameters of pain and ge...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751841/ https://www.ncbi.nlm.nih.gov/pubmed/31533626 http://dx.doi.org/10.1186/s12868-019-0531-7 |
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author | Staib-Lasarzik, Irina Nagel, Nadine Sebastiani, Anne Griemert, Eva-Verena Thal, Serge C. |
author_facet | Staib-Lasarzik, Irina Nagel, Nadine Sebastiani, Anne Griemert, Eva-Verena Thal, Serge C. |
author_sort | Staib-Lasarzik, Irina |
collection | PubMed |
description | BACKGROUND: In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is the reported use of analgesics. We determined surrogate parameters of pain and general well-being after subarachnoid hemorrhage (SAH), as well as the potential for improvement by different systemic analgesia paradigms. Brain injury was induced by filament perforation to mimic SAH. Sham-operated mice were included as surgical control groups with either neck or no-neck preparation. Mice with controlled cortical impact (CCI) injury were included as a control group with traumatic brain injury (TBI), but without neck preparation. Mice were randomized to buprenorphine, carprofen, meloxicam, or vehicle treatment. 24 h after SAH, CCI or sham surgery, pain and stress levels were assessed with a visual assessment score and the amount of food intake was recorded. RESULTS: Neck preparation, which is required to expose the surgical field for SAH induction, already increased pain/stress levels and sham surgeries for both CCI and SAH reduced food intake. Pain/stress levels were higher and food intake was lower after SAH compared with CCI. Pain/stress levels after CCI without analgesic treatment were similar to levels after SAH sham surgery. Pain treatment with buprenorphine was effective to reduce pain after SAH, whereas lower pain/stress intensity levels after CCI were not improved. CONCLUSION: This study emphasizes the importance of pain and stress assessment after surgeries and the efficacy of buprenorphine to improve pain and comfort levels after experimental SAH. |
format | Online Article Text |
id | pubmed-6751841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67518412019-09-23 Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage Staib-Lasarzik, Irina Nagel, Nadine Sebastiani, Anne Griemert, Eva-Verena Thal, Serge C. BMC Neurosci Research Article BACKGROUND: In animal research, authorities require a classification of anticipated pain levels and a perioperative analgesia protocol prior to approval of the experiments. However, data on this topic is rare and so is the reported use of analgesics. We determined surrogate parameters of pain and general well-being after subarachnoid hemorrhage (SAH), as well as the potential for improvement by different systemic analgesia paradigms. Brain injury was induced by filament perforation to mimic SAH. Sham-operated mice were included as surgical control groups with either neck or no-neck preparation. Mice with controlled cortical impact (CCI) injury were included as a control group with traumatic brain injury (TBI), but without neck preparation. Mice were randomized to buprenorphine, carprofen, meloxicam, or vehicle treatment. 24 h after SAH, CCI or sham surgery, pain and stress levels were assessed with a visual assessment score and the amount of food intake was recorded. RESULTS: Neck preparation, which is required to expose the surgical field for SAH induction, already increased pain/stress levels and sham surgeries for both CCI and SAH reduced food intake. Pain/stress levels were higher and food intake was lower after SAH compared with CCI. Pain/stress levels after CCI without analgesic treatment were similar to levels after SAH sham surgery. Pain treatment with buprenorphine was effective to reduce pain after SAH, whereas lower pain/stress intensity levels after CCI were not improved. CONCLUSION: This study emphasizes the importance of pain and stress assessment after surgeries and the efficacy of buprenorphine to improve pain and comfort levels after experimental SAH. BioMed Central 2019-09-18 /pmc/articles/PMC6751841/ /pubmed/31533626 http://dx.doi.org/10.1186/s12868-019-0531-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Staib-Lasarzik, Irina Nagel, Nadine Sebastiani, Anne Griemert, Eva-Verena Thal, Serge C. Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage |
title | Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage |
title_full | Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage |
title_fullStr | Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage |
title_full_unstemmed | Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage |
title_short | Analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage |
title_sort | analgesic treatment limits surrogate parameters for early stress and pain response after experimental subarachnoid hemorrhage |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751841/ https://www.ncbi.nlm.nih.gov/pubmed/31533626 http://dx.doi.org/10.1186/s12868-019-0531-7 |
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