Cargando…
Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis
OBJECTIVE: Resistance training (RT) can improve whole muscle strength without increasing muscle fiber size or contractility. Neural adaptations, which lead to greater neural activation of muscle, may mediate some of these improvements, particularly in older adults, where motor neuron denervation is...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751848/ https://www.ncbi.nlm.nih.gov/pubmed/31533814 http://dx.doi.org/10.1186/s13104-019-4642-0 |
_version_ | 1783452697583681536 |
---|---|
author | Voigt, Thomas B. Tourville, Timothy W. Falcone, Michael J. Slauterbeck, James R. Beynnon, Bruce D. Toth, Michael J. |
author_facet | Voigt, Thomas B. Tourville, Timothy W. Falcone, Michael J. Slauterbeck, James R. Beynnon, Bruce D. Toth, Michael J. |
author_sort | Voigt, Thomas B. |
collection | PubMed |
description | OBJECTIVE: Resistance training (RT) can improve whole muscle strength without increasing muscle fiber size or contractility. Neural adaptations, which lead to greater neural activation of muscle, may mediate some of these improvements, particularly in older adults, where motor neuron denervation is common. The purpose of this study was to explore the relationship of neural adaptations, as reflected by neural cell adhesion molecule (NCAM) expression, to improvements in (1) whole muscle strength and (2) muscle fiber size following RT in older adults with knee osteoarthritis. We performed whole muscle strength measurements and immunohistochemical analysis of fiber size, type, and NCAM expression before and after a 14-week RT program. RESULTS: RT increased whole-muscle strength as measured by 1-repetition maximum (1-RM) leg press (P = 0.01), leg extension (P = 0.03), and knee extensor peak torque (P = 0.050), but did not alter NCAM expression. Greater NCAM expression in myosin heavy chain (MHC) II fibers was associated with greater whole muscle strength gains (knee extensor peak torque r = 0.93; P < 0.01) and greater MHC II fiber size (r = 0.79; P < 0.01). Our results suggest that training-induced NCAM expression, and neural adaptations more generally, may be important for RT-induced morphological and functional improvements in older adults. Trial registration NCT01190046 |
format | Online Article Text |
id | pubmed-6751848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67518482019-09-23 Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis Voigt, Thomas B. Tourville, Timothy W. Falcone, Michael J. Slauterbeck, James R. Beynnon, Bruce D. Toth, Michael J. BMC Res Notes Research Note OBJECTIVE: Resistance training (RT) can improve whole muscle strength without increasing muscle fiber size or contractility. Neural adaptations, which lead to greater neural activation of muscle, may mediate some of these improvements, particularly in older adults, where motor neuron denervation is common. The purpose of this study was to explore the relationship of neural adaptations, as reflected by neural cell adhesion molecule (NCAM) expression, to improvements in (1) whole muscle strength and (2) muscle fiber size following RT in older adults with knee osteoarthritis. We performed whole muscle strength measurements and immunohistochemical analysis of fiber size, type, and NCAM expression before and after a 14-week RT program. RESULTS: RT increased whole-muscle strength as measured by 1-repetition maximum (1-RM) leg press (P = 0.01), leg extension (P = 0.03), and knee extensor peak torque (P = 0.050), but did not alter NCAM expression. Greater NCAM expression in myosin heavy chain (MHC) II fibers was associated with greater whole muscle strength gains (knee extensor peak torque r = 0.93; P < 0.01) and greater MHC II fiber size (r = 0.79; P < 0.01). Our results suggest that training-induced NCAM expression, and neural adaptations more generally, may be important for RT-induced morphological and functional improvements in older adults. Trial registration NCT01190046 BioMed Central 2019-09-18 /pmc/articles/PMC6751848/ /pubmed/31533814 http://dx.doi.org/10.1186/s13104-019-4642-0 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Note Voigt, Thomas B. Tourville, Timothy W. Falcone, Michael J. Slauterbeck, James R. Beynnon, Bruce D. Toth, Michael J. Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis |
title | Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis |
title_full | Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis |
title_fullStr | Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis |
title_full_unstemmed | Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis |
title_short | Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis |
title_sort | resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis |
topic | Research Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751848/ https://www.ncbi.nlm.nih.gov/pubmed/31533814 http://dx.doi.org/10.1186/s13104-019-4642-0 |
work_keys_str_mv | AT voigtthomasb resistancetraininginducedgainsinkneeextensorstrengtharerelatedtoincreasedneuralcelladhesionmoleculeexpressioninolderadultswithkneeosteoarthritis AT tourvilletimothyw resistancetraininginducedgainsinkneeextensorstrengtharerelatedtoincreasedneuralcelladhesionmoleculeexpressioninolderadultswithkneeosteoarthritis AT falconemichaelj resistancetraininginducedgainsinkneeextensorstrengtharerelatedtoincreasedneuralcelladhesionmoleculeexpressioninolderadultswithkneeosteoarthritis AT slauterbeckjamesr resistancetraininginducedgainsinkneeextensorstrengtharerelatedtoincreasedneuralcelladhesionmoleculeexpressioninolderadultswithkneeosteoarthritis AT beynnonbruced resistancetraininginducedgainsinkneeextensorstrengtharerelatedtoincreasedneuralcelladhesionmoleculeexpressioninolderadultswithkneeosteoarthritis AT tothmichaelj resistancetraininginducedgainsinkneeextensorstrengtharerelatedtoincreasedneuralcelladhesionmoleculeexpressioninolderadultswithkneeosteoarthritis |