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HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice

Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors. Epigenetic regulation of specific gene expression via impaired...

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Detalles Bibliográficos
Autores principales: Kim, Taewoo, Song, Seohoe, Park, Yeongwon, Kang, Sinil, Seo, Hyemyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751862/
https://www.ncbi.nlm.nih.gov/pubmed/31495079
http://dx.doi.org/10.5607/en.2019.28.4.504