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A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation

INTRODUCTION: The aim of this review is to test whether a gradual reduction in smoking results in a superior quit rate compared to abrupt cessation. METHODS: This review was based on Cochrane methodology for conducting meta-analysis. Only randomized controlled trials were eligible for this review. T...

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Autores principales: Tan, Jixiang, Zhao, Lin, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Publishing on behalf of the International Society for the Prevention of Tobacco Induced Diseases (ISPTID) 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752113/
https://www.ncbi.nlm.nih.gov/pubmed/31582921
http://dx.doi.org/10.18332/tid/100557
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author Tan, Jixiang
Zhao, Lin
Chen, Hong
author_facet Tan, Jixiang
Zhao, Lin
Chen, Hong
author_sort Tan, Jixiang
collection PubMed
description INTRODUCTION: The aim of this review is to test whether a gradual reduction in smoking results in a superior quit rate compared to abrupt cessation. METHODS: This review was based on Cochrane methodology for conducting meta-analysis. Only randomized controlled trials were eligible for this review. The participants were adult smokers who were addicted to tobacco, defined as those who smoked at least 15 cigarettes or 12.5 grams of loose-leaf tobacco daily or who had an end-expiratory carbon monoxide concentration of at least 15 ppm. Both groups used an equal amount of nicotine replacement therapy (NRT) before and after quitting smoking. The Review Manager Database (RevMan version 5.3) was used to analyze selected studies. RESULTS: Three randomized controlled trials involving 1607 patients were included. The prolonged abstinence rate of the gradual cessation group was significantly lower than that of the abrupt group (relative risk, RR=0.77). The result of 7-day smoking cessation rate was also lower in the gradual group (RR=0.76). CONCLUSIONS: Comparing the combination of NRT and abrupt cessation, the smoking cessation rate of the combination of NRT and gradual cessation is significantly lower. No significant adverse events were found in either group.
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spelling pubmed-67521132019-10-03 A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation Tan, Jixiang Zhao, Lin Chen, Hong Tob Induc Dis Research Paper INTRODUCTION: The aim of this review is to test whether a gradual reduction in smoking results in a superior quit rate compared to abrupt cessation. METHODS: This review was based on Cochrane methodology for conducting meta-analysis. Only randomized controlled trials were eligible for this review. The participants were adult smokers who were addicted to tobacco, defined as those who smoked at least 15 cigarettes or 12.5 grams of loose-leaf tobacco daily or who had an end-expiratory carbon monoxide concentration of at least 15 ppm. Both groups used an equal amount of nicotine replacement therapy (NRT) before and after quitting smoking. The Review Manager Database (RevMan version 5.3) was used to analyze selected studies. RESULTS: Three randomized controlled trials involving 1607 patients were included. The prolonged abstinence rate of the gradual cessation group was significantly lower than that of the abrupt group (relative risk, RR=0.77). The result of 7-day smoking cessation rate was also lower in the gradual group (RR=0.76). CONCLUSIONS: Comparing the combination of NRT and abrupt cessation, the smoking cessation rate of the combination of NRT and gradual cessation is significantly lower. No significant adverse events were found in either group. European Publishing on behalf of the International Society for the Prevention of Tobacco Induced Diseases (ISPTID) 2019-02-13 /pmc/articles/PMC6752113/ /pubmed/31582921 http://dx.doi.org/10.18332/tid/100557 Text en © 2019 Tan J https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License.
spellingShingle Research Paper
Tan, Jixiang
Zhao, Lin
Chen, Hong
A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation
title A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation
title_full A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation
title_fullStr A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation
title_full_unstemmed A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation
title_short A meta-analysis of the effectiveness of gradual versus abrupt smoking cessation
title_sort meta-analysis of the effectiveness of gradual versus abrupt smoking cessation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752113/
https://www.ncbi.nlm.nih.gov/pubmed/31582921
http://dx.doi.org/10.18332/tid/100557
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