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Lewy body constipation

We systematically reviewed literature regarding “Lewy body constipation”, i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms. Epidemiology and pathology studies showed that LBD can start with constipation alone, mostly due to neuronal loss and appearance of Lewy bod...

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Autores principales: Sakakibara, Ryuji, Doi, Hirokazu, Fukudo, Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Society of Coloproctology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752132/
https://www.ncbi.nlm.nih.gov/pubmed/31559362
http://dx.doi.org/10.23922/jarc.2018-022
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author Sakakibara, Ryuji
Doi, Hirokazu
Fukudo, Shin
author_facet Sakakibara, Ryuji
Doi, Hirokazu
Fukudo, Shin
author_sort Sakakibara, Ryuji
collection PubMed
description We systematically reviewed literature regarding “Lewy body constipation”, i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms. Epidemiology and pathology studies showed that LBD can start with constipation alone, mostly due to neuronal loss and appearance of Lewy bodies in the myenteric plexus. Because LBD significantly increases with age, “Lewy body constipation” may also increase with age. Neuroimaging methods such as metaiodobenzylguanidine (MIBG) scintigraphy and dopamine transporter (DAT) scan provide a way to detect “Lewy body constipation.” Key for “Lewy body constipation” includes minimal non-motor features such as REM sleep behavior disorder (night talking). Add-on therapy may be required to ameliorate constipation in patients. Diagnosis is not always easy; therefore, collaboration of gastroenterologists and neurologists is highly recommended to maximize patients' quality of life. In conclusion, “Lewy body constipation” might become a distinct category among geriatric constipation, regarding patients' follow-up and their management.
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spelling pubmed-67521322019-09-26 Lewy body constipation Sakakibara, Ryuji Doi, Hirokazu Fukudo, Shin J Anus Rectum Colon Review Article We systematically reviewed literature regarding “Lewy body constipation”, i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms. Epidemiology and pathology studies showed that LBD can start with constipation alone, mostly due to neuronal loss and appearance of Lewy bodies in the myenteric plexus. Because LBD significantly increases with age, “Lewy body constipation” may also increase with age. Neuroimaging methods such as metaiodobenzylguanidine (MIBG) scintigraphy and dopamine transporter (DAT) scan provide a way to detect “Lewy body constipation.” Key for “Lewy body constipation” includes minimal non-motor features such as REM sleep behavior disorder (night talking). Add-on therapy may be required to ameliorate constipation in patients. Diagnosis is not always easy; therefore, collaboration of gastroenterologists and neurologists is highly recommended to maximize patients' quality of life. In conclusion, “Lewy body constipation” might become a distinct category among geriatric constipation, regarding patients' follow-up and their management. The Japan Society of Coloproctology 2019-01-29 /pmc/articles/PMC6752132/ /pubmed/31559362 http://dx.doi.org/10.23922/jarc.2018-022 Text en Copyright © 2019 by The Japan Society of Coloproctology https://creativecommons.org/licenses/by-nc-nd/4.0/ Journal of the Anus, Rectum and Colon is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Sakakibara, Ryuji
Doi, Hirokazu
Fukudo, Shin
Lewy body constipation
title Lewy body constipation
title_full Lewy body constipation
title_fullStr Lewy body constipation
title_full_unstemmed Lewy body constipation
title_short Lewy body constipation
title_sort lewy body constipation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752132/
https://www.ncbi.nlm.nih.gov/pubmed/31559362
http://dx.doi.org/10.23922/jarc.2018-022
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