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Concentration polarization of ox-LDL activates autophagy and apoptosis via regulating LOX-1expression

Here we demonstrate that “concentration polarization” of ox-LDL enhances LOX-1 expression and ox-LDL uptake. It damages cell surface heparan sulfate proteoglycans (HSPG) and activates LOX-1 dependent autophagy and apoptosis. We also show that ox-LDL concentration polarization occurs on the surface o...

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Detalles Bibliográficos
Autores principales:	Ding, Zufeng, Liu, Shijie, Sun, Changqing, Chen, Zengsheng, Fan, Yubo, Deng, Xiaoyan, Wang, Xianwei, Mehta, Jawahar L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752645/ https://www.ncbi.nlm.nih.gov/pubmed/23807658 http://dx.doi.org/10.1038/srep02091

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