IL-10 signaling in dendritic cells controls IL-1β-mediated IFNγ secretion by human CD4(+) T cells: relevance to inflammatory bowel disease

Uncontrolled interferon γ (IFNγ)-mediated T-cell responses to commensal microbiota are a driver of inflammatory bowel disease (IBD). Interleukin-10 (IL-10) is crucial for controlling these T-cell responses, but the precise mechanism of inhibition remains unclear. A better understanding of how IL-10...

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Detalles Bibliográficos
Autores principales: Veenbergen, S, Li, P, Raatgeep, HC, Lindenbergh-Kortleve, DJ, Simons-Oosterhuis, Y, Farrel, A, Costes, LMM, Joosse, ME, van Berkel, LA, de Ruiter, LF, van Leeuwen, MA, Winter, D, Holland, SM, Freeman, AF, Wakabayashi, Y, Zhu, J, de Ridder, L, Driessen, GJ, Escher, JC, Leonard, WJ, Samsom, JN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752724/
https://www.ncbi.nlm.nih.gov/pubmed/31417161
http://dx.doi.org/10.1038/s41385-019-0194-9

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