RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery

The 3′ UTR (UTR) of human mRNAs plays a critical role in controlling protein expression and function. Importantly, 3′ UTRs of human messages are not invariant for each gene but rather are shaped by alternative polyadenylation (APA) in a cell state-dependent manner, including in response to T cell ac...

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Detalles Bibliográficos
Autores principales: Chatrikhi, Rakesh, Mallory, Michael J., Gazzara, Matthew R., Agosto, Laura M., Zhu, Wandi S., Litterman, Adam J., Ansel, K. Mark, Lynch, Kristen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752737/
https://www.ncbi.nlm.nih.gov/pubmed/31509743
http://dx.doi.org/10.1016/j.celrep.2019.08.022

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