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Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
Hippocampal interactions with the motor system are often assumed to reflect the role of memory in motor learning. Here, we examine hippocampal connectivity with sensorimotor cortex during two tasks requiring paced movements, one with a mnemonic component (sequence learning) and one without (repetiti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752792/ https://www.ncbi.nlm.nih.gov/pubmed/31536543 http://dx.doi.org/10.1371/journal.pone.0222064 |
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author | Burman, Douglas D. |
author_facet | Burman, Douglas D. |
author_sort | Burman, Douglas D. |
collection | PubMed |
description | Hippocampal interactions with the motor system are often assumed to reflect the role of memory in motor learning. Here, we examine hippocampal connectivity with sensorimotor cortex during two tasks requiring paced movements, one with a mnemonic component (sequence learning) and one without (repetitive tapping). Functional magnetic resonance imaging activity was recorded from thirteen right-handed subjects; connectivity was identified from sensorimotor cortex correlations with psychophysiological interactions in hippocampal activity between motor and passive visual tasks. Finger movements in both motor tasks anticipated the timing of the metronome, reflecting cognitive control, yet evidence of motor learning was limited to the sequence learning task; nonetheless, hippocampal connectivity was observed during both tasks. Connectivity from corresponding regions in the left and right hippocampus overlapped extensively, with improved sensitivity resulting from their conjunctive (global) analysis. Positive and negative connectivity were both evident, with positive connectivity in sensorimotor cortex ipsilateral to the moving hand during unilateral movements, whereas negative connectivity was prominent in whichever hemisphere was most active during movements. Results implicate the hippocampus in volitional finger movements even in the absence of motor learning or recall. |
format | Online Article Text |
id | pubmed-6752792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67527922019-09-27 Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning Burman, Douglas D. PLoS One Research Article Hippocampal interactions with the motor system are often assumed to reflect the role of memory in motor learning. Here, we examine hippocampal connectivity with sensorimotor cortex during two tasks requiring paced movements, one with a mnemonic component (sequence learning) and one without (repetitive tapping). Functional magnetic resonance imaging activity was recorded from thirteen right-handed subjects; connectivity was identified from sensorimotor cortex correlations with psychophysiological interactions in hippocampal activity between motor and passive visual tasks. Finger movements in both motor tasks anticipated the timing of the metronome, reflecting cognitive control, yet evidence of motor learning was limited to the sequence learning task; nonetheless, hippocampal connectivity was observed during both tasks. Connectivity from corresponding regions in the left and right hippocampus overlapped extensively, with improved sensitivity resulting from their conjunctive (global) analysis. Positive and negative connectivity were both evident, with positive connectivity in sensorimotor cortex ipsilateral to the moving hand during unilateral movements, whereas negative connectivity was prominent in whichever hemisphere was most active during movements. Results implicate the hippocampus in volitional finger movements even in the absence of motor learning or recall. Public Library of Science 2019-09-19 /pmc/articles/PMC6752792/ /pubmed/31536543 http://dx.doi.org/10.1371/journal.pone.0222064 Text en © 2019 Douglas D. Burman http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Burman, Douglas D. Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning |
title | Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning |
title_full | Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning |
title_fullStr | Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning |
title_full_unstemmed | Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning |
title_short | Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning |
title_sort | hippocampal connectivity with sensorimotor cortex during volitional finger movements: laterality and relationship to motor learning |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752792/ https://www.ncbi.nlm.nih.gov/pubmed/31536543 http://dx.doi.org/10.1371/journal.pone.0222064 |
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