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Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis

OBJECTIVE: Mycobacterium marinum causes a rare cutaneous disease known as fish tank granuloma (FTG). The disease manifestations resemble those associated with Cutaneous Leishmaniasis (CL). The aim of this study was to determine whether FTG was the cause of cutaneous lesions in patients who were refe...

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Autores principales: Fata, Abdolmajid, Bojdy, Amin, Maleki, Masoud, Hosseini Farash, Bibi Razieh, Ghazvini, Kiarash, Tajzadeh, Parastoo, Vakili, Vida, Moghaddas, Elham, Mastroeni, Pietro, Rahmani, Shadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752854/
https://www.ncbi.nlm.nih.gov/pubmed/31536497
http://dx.doi.org/10.1371/journal.pone.0221367
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author Fata, Abdolmajid
Bojdy, Amin
Maleki, Masoud
Hosseini Farash, Bibi Razieh
Ghazvini, Kiarash
Tajzadeh, Parastoo
Vakili, Vida
Moghaddas, Elham
Mastroeni, Pietro
Rahmani, Shadi
author_facet Fata, Abdolmajid
Bojdy, Amin
Maleki, Masoud
Hosseini Farash, Bibi Razieh
Ghazvini, Kiarash
Tajzadeh, Parastoo
Vakili, Vida
Moghaddas, Elham
Mastroeni, Pietro
Rahmani, Shadi
author_sort Fata, Abdolmajid
collection PubMed
description OBJECTIVE: Mycobacterium marinum causes a rare cutaneous disease known as fish tank granuloma (FTG). The disease manifestations resemble those associated with Cutaneous Leishmaniasis (CL). The aim of this study was to determine whether FTG was the cause of cutaneous lesions in patients who were referred to the Parasitology laboratory of Imam Reza Hospital in Mashhad to be investigated for CL. MATERIALS/METHODS: One hundered patients, clinically diagnosed with CL between April 2014 and March 2015, were included in this study. Ziehl-Neelsen staining was performed to identify acid-fast Mycobacterium in addition to bacterial cultures using Löwenstein-Jensen medium. Skin lesion samples were also collected and kept on DNA banking cards for PCR testing. RESULTS: Twenty-nine of the 100 individuals with skin lesions, and therefore suspected of suffering from CL, tested positive for Mycobacterium marinum by PCR. Of these, 21 (72.4%) were male and 8(27.6%) were female. In 97% of these cases the lesions were located on hands and fingers. These patients had a history of manipulating fish and had been in contact with aquarium water. A sporotrichoid appearance was observed in 58.6% of the patients with mycobacterial lesions; 67% of patients had multiple head appearance. CONCLUSION: Patients suspected to have CL and who test negative for CL could be affected by FTG. Therefore, after obtaining an accurate case history, molecular diagnosis is recommended for cases that give a negative result by conventional methods.
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spelling pubmed-67528542019-09-27 Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis Fata, Abdolmajid Bojdy, Amin Maleki, Masoud Hosseini Farash, Bibi Razieh Ghazvini, Kiarash Tajzadeh, Parastoo Vakili, Vida Moghaddas, Elham Mastroeni, Pietro Rahmani, Shadi PLoS One Research Article OBJECTIVE: Mycobacterium marinum causes a rare cutaneous disease known as fish tank granuloma (FTG). The disease manifestations resemble those associated with Cutaneous Leishmaniasis (CL). The aim of this study was to determine whether FTG was the cause of cutaneous lesions in patients who were referred to the Parasitology laboratory of Imam Reza Hospital in Mashhad to be investigated for CL. MATERIALS/METHODS: One hundered patients, clinically diagnosed with CL between April 2014 and March 2015, were included in this study. Ziehl-Neelsen staining was performed to identify acid-fast Mycobacterium in addition to bacterial cultures using Löwenstein-Jensen medium. Skin lesion samples were also collected and kept on DNA banking cards for PCR testing. RESULTS: Twenty-nine of the 100 individuals with skin lesions, and therefore suspected of suffering from CL, tested positive for Mycobacterium marinum by PCR. Of these, 21 (72.4%) were male and 8(27.6%) were female. In 97% of these cases the lesions were located on hands and fingers. These patients had a history of manipulating fish and had been in contact with aquarium water. A sporotrichoid appearance was observed in 58.6% of the patients with mycobacterial lesions; 67% of patients had multiple head appearance. CONCLUSION: Patients suspected to have CL and who test negative for CL could be affected by FTG. Therefore, after obtaining an accurate case history, molecular diagnosis is recommended for cases that give a negative result by conventional methods. Public Library of Science 2019-09-19 /pmc/articles/PMC6752854/ /pubmed/31536497 http://dx.doi.org/10.1371/journal.pone.0221367 Text en © 2019 Fata et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fata, Abdolmajid
Bojdy, Amin
Maleki, Masoud
Hosseini Farash, Bibi Razieh
Ghazvini, Kiarash
Tajzadeh, Parastoo
Vakili, Vida
Moghaddas, Elham
Mastroeni, Pietro
Rahmani, Shadi
Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
title Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
title_full Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
title_fullStr Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
title_full_unstemmed Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
title_short Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
title_sort fish tank granuloma: an emerging skin disease in iran mimicking cutaneous leishmaniasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752854/
https://www.ncbi.nlm.nih.gov/pubmed/31536497
http://dx.doi.org/10.1371/journal.pone.0221367
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