Targeting Cardiac Fibrosis with Engineered T cells

Fibrosis is observed in nearly every form of myocardial disease(1). Upon injury, cardiac fibroblasts (CF) in the heart begin to remodel the myocardium via extracellular matrix deposition, resulting in increased tissue stiffness and reduced compliance. Excessive cardiac fibrosis is an important facto...

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Detalles Bibliográficos
Autores principales: Aghajanian, Haig, Kimura, Toru, Rurik, Joel G., Hancock, Aidan S., Leibowitz, Michael S., Li, Li, Scholler, John, Monslow, James, Lo, Albert, Han, Wei, Wang, Tao, Bedi, Kenneth, Morley, Michael P., Saldana, Ricardo A. Linares, Bolar, Nikhita A., McDaid, Kendra, Assenmacher, Charles-Antoine, Smith, Cheryl L., Wirth, Dagmar, June, Carl H., Margulies, Kenneth B., Jain, Rajan, Puré, Ellen, Albelda, Steven M., Epstein, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752964/
https://www.ncbi.nlm.nih.gov/pubmed/31511695
http://dx.doi.org/10.1038/s41586-019-1546-z

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