Microarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations

Here, we show that human Connexin 26 (hCx26 or Cx26WT) hemichannel opening rapidly enables the transport of small molecules when triggered by temperature and by compensation of the Ca(2+) blockade with EDTA. Point mutations within Cx26 were analysed by a novel optical microarray-based Lucifer Yellow...

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Detalles Bibliográficos
Autores principales: Wang, Hongling, Stahl, Frank, Scheper, Thomas, Steffens, Melanie, Warnecke, Athanasia, Zeilinger, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753059/
https://www.ncbi.nlm.nih.gov/pubmed/31537823
http://dx.doi.org/10.1038/s41598-019-49423-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753059/
https://www.ncbi.nlm.nih.gov/pubmed/31537823
http://dx.doi.org/10.1038/s41598-019-49423-3

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