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Microarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations
Here, we show that human Connexin 26 (hCx26 or Cx26WT) hemichannel opening rapidly enables the transport of small molecules when triggered by temperature and by compensation of the Ca(2+) blockade with EDTA. Point mutations within Cx26 were analysed by a novel optical microarray-based Lucifer Yellow...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753059/ https://www.ncbi.nlm.nih.gov/pubmed/31537823 http://dx.doi.org/10.1038/s41598-019-49423-3 |