MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify anti-R-loop mechanisms, we performed a genome-wide trigeni...

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Detalles Bibliográficos
Autores principales: Chang, Emily Yun-Chia, Tsai, Shuhe, Aristizabal, Maria J., Wells, James P., Coulombe, Yan, Busatto, Franciele F., Chan, Yujia A., Kumar, Arun, Dan Zhu, Yi, Wang, Alan Ying-Hsu, Fournier, Louis-Alexandre, Hieter, Philip, Kobor, Michael S., Masson, Jean-Yves, Stirling, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753070/
https://www.ncbi.nlm.nih.gov/pubmed/31537797
http://dx.doi.org/10.1038/s41467-019-12271-w

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