The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Macrophage-expressed gene 1 (MPEG1/Perforin-2) is a perforin-like protein that functions within the phagolysosome to damage engulfed microbes. MPEG1 is thought to form pores in target membranes, however, its mode of action remains unknown. We use cryo-Electron Microscopy (cryo-EM) to determine the 2...

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Detalles Bibliográficos
Autores principales: Pang, Siew Siew, Bayly-Jones, Charles, Radjainia, Mazdak, Spicer, Bradley A., Law, Ruby H. P., Hodel, Adrian W., Parsons, Edward S., Ekkel, Susan M., Conroy, Paul J., Ramm, Georg, Venugopal, Hariprasad, Bird, Phillip I., Hoogenboom, Bart W., Voskoboinik, Ilia, Gambin, Yann, Sierecki, Emma, Dunstone, Michelle A., Whisstock, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753088/
https://www.ncbi.nlm.nih.gov/pubmed/31537793
http://dx.doi.org/10.1038/s41467-019-12279-2

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