Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling

The endothelial glycocalyx and its regulated shedding are important to vascular health. Endo-β-D-glucuronidase heparanase-1 (HPSE1) is the only enzyme that can shed heparan sulfate. However, the mechanisms are not well understood. We show that HPSE1 activity aggravated Toll-like receptor 4 (TLR4)-me...

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Detalles Bibliográficos
Autores principales: Kiyan, Yulia, Tkachuk, Sergey, Kurselis, Kestutis, Shushakova, Nelli, Stahl, Klaus, Dawodu, Damilola, Kiyan, Roman, Chichkov, Boris, Haller, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753096/
https://www.ncbi.nlm.nih.gov/pubmed/31537875
http://dx.doi.org/10.1038/s41598-019-50068-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753096/
https://www.ncbi.nlm.nih.gov/pubmed/31537875
http://dx.doi.org/10.1038/s41598-019-50068-5

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