DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial methylation domains. Here we find that immunomodul...

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Detalles Bibliográficos
Autores principales: Jung, Hyunchul, Kim, Hong Sook, Kim, Jeong Yeon, Sun, Jong-Mu, Ahn, Jin Seok, Ahn, Myung-Ju, Park, Keunchil, Esteller, Manel, Lee, Se-Hoon, Choi, Jung Kyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753140/
https://www.ncbi.nlm.nih.gov/pubmed/31537801
http://dx.doi.org/10.1038/s41467-019-12159-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753140/
https://www.ncbi.nlm.nih.gov/pubmed/31537801
http://dx.doi.org/10.1038/s41467-019-12159-9

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