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IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and e...

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Detalles Bibliográficos
Autores principales:	Catanzaro, Jason R., Strauss, Juliet D., Bielecka, Agata, Porto, Anthony F., Lobo, Francis M., Urban, Andrea, Schofield, Whitman B., Palm, Noah W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753154/ https://www.ncbi.nlm.nih.gov/pubmed/31537840 http://dx.doi.org/10.1038/s41598-019-49923-2

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