Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 strains in animal models. However, NAb responses are relatively weak and narrow in specificity. Displaying antigens in a multi...

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Detalles Bibliográficos
Autores principales: Brouwer, Philip J. M., Antanasijevic, Aleksandar, Berndsen, Zachary, Yasmeen, Anila, Fiala, Brooke, Bijl, Tom P. L., Bontjer, Ilja, Bale, Jacob B., Sheffler, William, Allen, Joel D., Schorcht, Anna, Burger, Judith A., Camacho, Miguel, Ellis, Daniel, Cottrell, Christopher A., Behrens, Anna-Janina, Catalano, Marco, del Moral-Sánchez, Iván, Ketas, Thomas J., LaBranche, Celia, van Gils, Marit J., Sliepen, Kwinten, Stewart, Lance J., Crispin, Max, Montefiori, David C., Baker, David, Moore, John P., Klasse, Per Johan, Ward, Andrew B., King, Neil P., Sanders, Rogier W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753213/
https://www.ncbi.nlm.nih.gov/pubmed/31537780
http://dx.doi.org/10.1038/s41467-019-12080-1

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