Cargando…

Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time

Pregnancy is influenced by the circadian (“circa” or approximately; diēm or day) system, which coordinates physiology and behavior with predictable daily changes in the environment such as light/dark cycles. For example, most species deliver around a particular time of day. In mammals, circadian rhy...

Descripción completa

Detalles Bibliográficos
Autores principales: McCarthy, Ronald, Jungheim, Emily S., Fay, Justin C., Bates, Keenan, Herzog, Erik D., England, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753220/
https://www.ncbi.nlm.nih.gov/pubmed/31572299
http://dx.doi.org/10.3389/fendo.2019.00616
_version_ 1783452855740399616
author McCarthy, Ronald
Jungheim, Emily S.
Fay, Justin C.
Bates, Keenan
Herzog, Erik D.
England, Sarah K.
author_facet McCarthy, Ronald
Jungheim, Emily S.
Fay, Justin C.
Bates, Keenan
Herzog, Erik D.
England, Sarah K.
author_sort McCarthy, Ronald
collection PubMed
description Pregnancy is influenced by the circadian (“circa” or approximately; diēm or day) system, which coordinates physiology and behavior with predictable daily changes in the environment such as light/dark cycles. For example, most species deliver around a particular time of day. In mammals, circadian rhythms are controlled by the master circadian pacemaker, the suprachiasmatic nucleus. One key way that the suprachiasmatic nucleus coordinates circadian rhythms throughout the body is by regulating production of the sleep-promoting hormone melatonin. Serum melatonin concentration, which peaks at night and is suppressed during the day, is one of the best biological indicators of circadian timing. Circadian misalignment causes maternal disturbances in the temporal organization of many physiological processes including melatonin synthesis, and these disturbances of the circadian system have been linked to an increased risk for pregnancy complications. Here, we review evidence that melatonin helps regulate the maternal and fetal circadian systems and the timing of birth. Finally, we discuss the potential for melatonin-based therapeutic strategies to alleviate poor pregnancy outcomes such as preeclampsia and preterm birth.
format Online
Article
Text
id pubmed-6753220
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-67532202019-09-30 Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time McCarthy, Ronald Jungheim, Emily S. Fay, Justin C. Bates, Keenan Herzog, Erik D. England, Sarah K. Front Endocrinol (Lausanne) Endocrinology Pregnancy is influenced by the circadian (“circa” or approximately; diēm or day) system, which coordinates physiology and behavior with predictable daily changes in the environment such as light/dark cycles. For example, most species deliver around a particular time of day. In mammals, circadian rhythms are controlled by the master circadian pacemaker, the suprachiasmatic nucleus. One key way that the suprachiasmatic nucleus coordinates circadian rhythms throughout the body is by regulating production of the sleep-promoting hormone melatonin. Serum melatonin concentration, which peaks at night and is suppressed during the day, is one of the best biological indicators of circadian timing. Circadian misalignment causes maternal disturbances in the temporal organization of many physiological processes including melatonin synthesis, and these disturbances of the circadian system have been linked to an increased risk for pregnancy complications. Here, we review evidence that melatonin helps regulate the maternal and fetal circadian systems and the timing of birth. Finally, we discuss the potential for melatonin-based therapeutic strategies to alleviate poor pregnancy outcomes such as preeclampsia and preterm birth. Frontiers Media S.A. 2019-09-13 /pmc/articles/PMC6753220/ /pubmed/31572299 http://dx.doi.org/10.3389/fendo.2019.00616 Text en Copyright © 2019 McCarthy, Jungheim, Fay, Bates, Herzog and England. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
McCarthy, Ronald
Jungheim, Emily S.
Fay, Justin C.
Bates, Keenan
Herzog, Erik D.
England, Sarah K.
Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time
title Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time
title_full Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time
title_fullStr Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time
title_full_unstemmed Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time
title_short Riding the Rhythm of Melatonin Through Pregnancy to Deliver on Time
title_sort riding the rhythm of melatonin through pregnancy to deliver on time
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753220/
https://www.ncbi.nlm.nih.gov/pubmed/31572299
http://dx.doi.org/10.3389/fendo.2019.00616
work_keys_str_mv AT mccarthyronald ridingtherhythmofmelatoninthroughpregnancytodeliverontime
AT jungheimemilys ridingtherhythmofmelatoninthroughpregnancytodeliverontime
AT fayjustinc ridingtherhythmofmelatoninthroughpregnancytodeliverontime
AT bateskeenan ridingtherhythmofmelatoninthroughpregnancytodeliverontime
AT herzogerikd ridingtherhythmofmelatoninthroughpregnancytodeliverontime
AT englandsarahk ridingtherhythmofmelatoninthroughpregnancytodeliverontime