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Natural and Synthetic Sialylated Glycan Microarrays and Their Applications
This focused chapter serves as a short survey of glycan microarrays that are available with sialylated glycans, including both defined and shotgun arrays, their generation, and their utility in studying differential binding interactions to sialylated compounds, highlighting N-glycolyl (Gc) modified...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753469/ https://www.ncbi.nlm.nih.gov/pubmed/31572731 http://dx.doi.org/10.3389/fmolb.2019.00088 |
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author | McQuillan, Alyssa M. Byrd-Leotis, Lauren Heimburg-Molinaro, Jamie Cummings, Richard D. |
author_facet | McQuillan, Alyssa M. Byrd-Leotis, Lauren Heimburg-Molinaro, Jamie Cummings, Richard D. |
author_sort | McQuillan, Alyssa M. |
collection | PubMed |
description | This focused chapter serves as a short survey of glycan microarrays that are available with sialylated glycans, including both defined and shotgun arrays, their generation, and their utility in studying differential binding interactions to sialylated compounds, highlighting N-glycolyl (Gc) modified sialylated compounds. A brief discussion of binding interactions by lectins, antibodies, and viruses, and their relevance that have been observed with sialylated glycan microarrays is presented, as well as a discussion of cross-comparisons of array platforms and efforts to centralize and standardize the glycan microarray data. |
format | Online Article Text |
id | pubmed-6753469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67534692019-09-30 Natural and Synthetic Sialylated Glycan Microarrays and Their Applications McQuillan, Alyssa M. Byrd-Leotis, Lauren Heimburg-Molinaro, Jamie Cummings, Richard D. Front Mol Biosci Molecular Biosciences This focused chapter serves as a short survey of glycan microarrays that are available with sialylated glycans, including both defined and shotgun arrays, their generation, and their utility in studying differential binding interactions to sialylated compounds, highlighting N-glycolyl (Gc) modified sialylated compounds. A brief discussion of binding interactions by lectins, antibodies, and viruses, and their relevance that have been observed with sialylated glycan microarrays is presented, as well as a discussion of cross-comparisons of array platforms and efforts to centralize and standardize the glycan microarray data. Frontiers Media S.A. 2019-09-13 /pmc/articles/PMC6753469/ /pubmed/31572731 http://dx.doi.org/10.3389/fmolb.2019.00088 Text en Copyright © 2019 McQuillan, Byrd-Leotis, Heimburg-Molinaro and Cummings. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences McQuillan, Alyssa M. Byrd-Leotis, Lauren Heimburg-Molinaro, Jamie Cummings, Richard D. Natural and Synthetic Sialylated Glycan Microarrays and Their Applications |
title | Natural and Synthetic Sialylated Glycan Microarrays and Their Applications |
title_full | Natural and Synthetic Sialylated Glycan Microarrays and Their Applications |
title_fullStr | Natural and Synthetic Sialylated Glycan Microarrays and Their Applications |
title_full_unstemmed | Natural and Synthetic Sialylated Glycan Microarrays and Their Applications |
title_short | Natural and Synthetic Sialylated Glycan Microarrays and Their Applications |
title_sort | natural and synthetic sialylated glycan microarrays and their applications |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753469/ https://www.ncbi.nlm.nih.gov/pubmed/31572731 http://dx.doi.org/10.3389/fmolb.2019.00088 |
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