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Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability

The postreplication repair gene, HLTF, is often amplified and overexpressed in cancer. Here we model HLTF dysregulation through the functionally conserved Saccharomyces cerevisiae ortholog, RAD5. Genetic interaction profiling and landscape enrichment analysis of RAD5 overexpression (RAD5(OE)) reveal...

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Detalles Bibliográficos
Autores principales:	Bryant, Eric E, Šunjevarić, Ivana, Berchowitz, Luke, Rothstein, Rodney, Reid, Robert J D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753471/ https://www.ncbi.nlm.nih.gov/pubmed/31350889 http://dx.doi.org/10.1093/nar/gkz631

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