DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation

Most human cancers acquire mutations causing defects in the p53 signaling pathway. The tumor suppressor p53 becomes activated in response to genotoxic stress and is essential for arresting the cell cycle to facilitate DNA repair or to initiate apoptosis. p53-induced cell cycle-arrest is mediated by...

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Detalles Bibliográficos
Autores principales: Uxa, Sigrid, Bernhart, Stephan H, Mages, Christina F S, Fischer, Martin, Kohler, Robin, Hoffmann, Steve, Stadler, Peter F, Engeland, Kurt, Müller, Gerd A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753476/
https://www.ncbi.nlm.nih.gov/pubmed/31400114
http://dx.doi.org/10.1093/nar/gkz635

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