Staufen1 and UPF1 exert opposite actions on the replacement of the nuclear cap-binding complex by eIF4E at the 5′ end of mRNAs

Newly synthesized mRNAs are exported from the nucleus to cytoplasm with a 5′-cap structure bound by the nuclear cap-binding complex (CBC). During or after export, the CBC should be properly replaced by cytoplasmic cap-binding protein eIF4E for efficient protein synthesis. Nonetheless, little is know...

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Autores principales: Jeong, Kwon, Ryu, Incheol, Park, Joori, Hwang, Hyun Jung, Ha, Hongseok, Park, Yeonkyoung, Oh, Sang Taek, Kim, Yoon Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753478/
https://www.ncbi.nlm.nih.gov/pubmed/31361897
http://dx.doi.org/10.1093/nar/gkz643

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