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Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction

OBJECTIVE: This study was performed to evaluate the clinical application value of carotid artery color Doppler ultrasonography and the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and cystatin C (Cys C) in the diagnosis and treatment of arteriosclerotic cerebral infarction. MET...

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Autores principales: Huang, Lei, Yao, Shengguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753554/
https://www.ncbi.nlm.nih.gov/pubmed/31342824
http://dx.doi.org/10.1177/0300060519859141
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author Huang, Lei
Yao, Shengguo
author_facet Huang, Lei
Yao, Shengguo
author_sort Huang, Lei
collection PubMed
description OBJECTIVE: This study was performed to evaluate the clinical application value of carotid artery color Doppler ultrasonography and the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and cystatin C (Cys C) in the diagnosis and treatment of arteriosclerotic cerebral infarction. METHODS: Sixty patients with arteriosclerotic cerebral infarction and 60 matched healthy participants were included. The patients were divided into mild, moderate, and severe groups according to their National Institutes of Health Stroke Scale (NIHSS) scores. Carotid artery intima plaque formation and the intima–media thickness (IMT) were observed using carotid artery color Doppler ultrasonography. The correlation between IMT and the Lp-PLA2 or Cys C level was statistically analyzed. RESULTS: Patients with arteriosclerotic cerebral infarction had a higher detection rate of carotid plaques, especially unstable plaques, than healthy participants. The plasma levels of Lp-PLA2 and Cys C were elevated in patients with arteriosclerotic cerebral infarction and increased with the NIHSS scores. The plasma levels of Lp-PLA2 and Cys C in patients with arteriosclerotic cerebral infarction were correlated with IMT. CONCLUSION: The combination of carotid artery color Doppler ultrasonography with the Lp-PLA2 and Cys C plasma levels is of great clinical value in the diagnosis and treatment of arteriosclerotic cerebral infarction.
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spelling pubmed-67535542019-09-25 Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction Huang, Lei Yao, Shengguo J Int Med Res Clinical Research Reports OBJECTIVE: This study was performed to evaluate the clinical application value of carotid artery color Doppler ultrasonography and the plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and cystatin C (Cys C) in the diagnosis and treatment of arteriosclerotic cerebral infarction. METHODS: Sixty patients with arteriosclerotic cerebral infarction and 60 matched healthy participants were included. The patients were divided into mild, moderate, and severe groups according to their National Institutes of Health Stroke Scale (NIHSS) scores. Carotid artery intima plaque formation and the intima–media thickness (IMT) were observed using carotid artery color Doppler ultrasonography. The correlation between IMT and the Lp-PLA2 or Cys C level was statistically analyzed. RESULTS: Patients with arteriosclerotic cerebral infarction had a higher detection rate of carotid plaques, especially unstable plaques, than healthy participants. The plasma levels of Lp-PLA2 and Cys C were elevated in patients with arteriosclerotic cerebral infarction and increased with the NIHSS scores. The plasma levels of Lp-PLA2 and Cys C in patients with arteriosclerotic cerebral infarction were correlated with IMT. CONCLUSION: The combination of carotid artery color Doppler ultrasonography with the Lp-PLA2 and Cys C plasma levels is of great clinical value in the diagnosis and treatment of arteriosclerotic cerebral infarction. SAGE Publications 2019-07-25 2019-09 /pmc/articles/PMC6753554/ /pubmed/31342824 http://dx.doi.org/10.1177/0300060519859141 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Research Reports
Huang, Lei
Yao, Shengguo
Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction
title Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction
title_full Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction
title_fullStr Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction
title_full_unstemmed Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction
title_short Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction
title_sort carotid artery color doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase a2 and cystatin c in arteriosclerotic cerebral infarction
topic Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753554/
https://www.ncbi.nlm.nih.gov/pubmed/31342824
http://dx.doi.org/10.1177/0300060519859141
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