Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology

The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. This is made possible by their unique recognition properties and v...

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Detalles Bibliográficos
Autores principales: Das, Debapratim, Assaf, Khaleel I., Nau, Werner M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753627/
https://www.ncbi.nlm.nih.gov/pubmed/31572710
http://dx.doi.org/10.3389/fchem.2019.00619
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author Das, Debapratim
Assaf, Khaleel I.
Nau, Werner M.
author_facet Das, Debapratim
Assaf, Khaleel I.
Nau, Werner M.
author_sort Das, Debapratim
collection PubMed
description The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. This is made possible by their unique recognition properties and very low cytotoxicity. In this review, we summarize the host-guest complexation of biologically important molecules with CBn, and highlight their implementation in medicinal chemistry and chemical biology.
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spelling pubmed-67536272019-09-30 Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology Das, Debapratim Assaf, Khaleel I. Nau, Werner M. Front Chem Chemistry The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. This is made possible by their unique recognition properties and very low cytotoxicity. In this review, we summarize the host-guest complexation of biologically important molecules with CBn, and highlight their implementation in medicinal chemistry and chemical biology. Frontiers Media S.A. 2019-09-13 /pmc/articles/PMC6753627/ /pubmed/31572710 http://dx.doi.org/10.3389/fchem.2019.00619 Text en Copyright © 2019 Das, Assaf and Nau. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Das, Debapratim
Assaf, Khaleel I.
Nau, Werner M.
Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology
title Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology
title_full Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology
title_fullStr Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology
title_full_unstemmed Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology
title_short Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology
title_sort applications of cucurbiturils in medicinal chemistry and chemical biology
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753627/
https://www.ncbi.nlm.nih.gov/pubmed/31572710
http://dx.doi.org/10.3389/fchem.2019.00619
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