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Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study

BACKGROUND: The pelvis is one of the primary sites of Ewing sarcoma (ES) and is associated with poorer prognoses than the extremities. Due to the rarity of this disease and limited data available, the prognostic factors of pelvic ES remain controversial. Thus, this study aimed to identify independen...

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Autores principales: Chen, Li, Long, Cheng, Liu, Jiaxin, Xing, Fei, Duan, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753919/
https://www.ncbi.nlm.nih.gov/pubmed/31576245
http://dx.doi.org/10.7717/peerj.7710
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author Chen, Li
Long, Cheng
Liu, Jiaxin
Xing, Fei
Duan, Xin
author_facet Chen, Li
Long, Cheng
Liu, Jiaxin
Xing, Fei
Duan, Xin
author_sort Chen, Li
collection PubMed
description BACKGROUND: The pelvis is one of the primary sites of Ewing sarcoma (ES) and is associated with poorer prognoses than the extremities. Due to the rarity of this disease and limited data available, the prognostic factors of pelvic ES remain controversial. Thus, this study aimed to identify independent prognostic factors, and develop a nomogram for predicting survival rates in patients with pelvic ES. METHODS: Using data provided by the Surveillance, Epidemiology, and End Results (SEER) database, variables including age, sex, race, tumor size, tumor stage, surgery, and radiotherapy were analyzed using the Kaplan–Meier method and Cox proportional hazards regression. Based on the results of multivariate analyses, a nomogram was built to predict the overall survival (OS) of patients with pelvic ES. The performance of the nomogram was evaluated by the concordance index (C-index). RESULTS: A total of 267 cases diagnosed between 2004 and 2016 were included in the study. Univariate and multivariate analyses showed that patients who were younger, white, had a localized tumor stage, or underwent surgery were associated with improved prognoses, while no significant differences were observed in OS based on sex, tumor size, or radiotherapy. A nomogram was developed and the C-index was 0.728, indicating adequate performance for survival prediction. CONCLUSIONS: Age, race, tumor stage, and surgery were identified as independent prognostic factors for the OS of pelvic ES. The nomogram developed in this study can individually predict 3- and 5-year OS in patients with pelvic ES.
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spelling pubmed-67539192019-10-01 Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study Chen, Li Long, Cheng Liu, Jiaxin Xing, Fei Duan, Xin PeerJ Oncology BACKGROUND: The pelvis is one of the primary sites of Ewing sarcoma (ES) and is associated with poorer prognoses than the extremities. Due to the rarity of this disease and limited data available, the prognostic factors of pelvic ES remain controversial. Thus, this study aimed to identify independent prognostic factors, and develop a nomogram for predicting survival rates in patients with pelvic ES. METHODS: Using data provided by the Surveillance, Epidemiology, and End Results (SEER) database, variables including age, sex, race, tumor size, tumor stage, surgery, and radiotherapy were analyzed using the Kaplan–Meier method and Cox proportional hazards regression. Based on the results of multivariate analyses, a nomogram was built to predict the overall survival (OS) of patients with pelvic ES. The performance of the nomogram was evaluated by the concordance index (C-index). RESULTS: A total of 267 cases diagnosed between 2004 and 2016 were included in the study. Univariate and multivariate analyses showed that patients who were younger, white, had a localized tumor stage, or underwent surgery were associated with improved prognoses, while no significant differences were observed in OS based on sex, tumor size, or radiotherapy. A nomogram was developed and the C-index was 0.728, indicating adequate performance for survival prediction. CONCLUSIONS: Age, race, tumor stage, and surgery were identified as independent prognostic factors for the OS of pelvic ES. The nomogram developed in this study can individually predict 3- and 5-year OS in patients with pelvic ES. PeerJ Inc. 2019-09-17 /pmc/articles/PMC6753919/ /pubmed/31576245 http://dx.doi.org/10.7717/peerj.7710 Text en © 2019 Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Oncology
Chen, Li
Long, Cheng
Liu, Jiaxin
Xing, Fei
Duan, Xin
Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study
title Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study
title_full Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study
title_fullStr Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study
title_full_unstemmed Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study
title_short Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study
title_sort characteristics and prognosis of pelvic ewing sarcoma: a seer population-based study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753919/
https://www.ncbi.nlm.nih.gov/pubmed/31576245
http://dx.doi.org/10.7717/peerj.7710
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